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Tyrosine metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
ATP + 4-hydroxyphenylacetate + CoA <=> AMP + diphosphate + 4-hydroxyphenylacetyl-CoA 6.2.1
6.2.1.30 phenylacetate---CoA ligase
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succinate_semialdehyde + NADP+ + H2O <=> NADPH + succinate + H+ 1.1.1.21 aldose reductase
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+)
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L-tyrosine <=> 3-amino-3-(4-hydroxyphenyl)propanoate 5.4.3.6 tyrosine 2,3-aminomutase
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4-(2-hydroxyethyl)phenol + NAD+ <=> H+ + 4-hydroxyphenylacetaldehyde + NADH 1.1.1.1 alcohol dehydrogenase
1.1.1.21 aldose reductase
1.1.1.90 aryl-alcohol dehydrogenase
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2 3,5-diiodo-L-tyrosine + H2O2 <=> L-thyroxine + 2-aminoacrylate + 2 H2O 1.11.1.8 iodide peroxidase
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H+ + 2,5-Dihydroxybenzoate <=> CO2 + hydroquinone 4.1.1.46 o-pyrocatechuate decarboxylase
4.1.1.62 gentisate decarboxylase
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UDP-glucose + 4-(2-hydroxyethyl)phenol <=> salidroside + UDP + H+ 2.4.1
2.4.1.35 phenol beta-glucosyltransferase
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S-adenosyl-L-methionine + 3,4-Dihydroxyphenylacetate <=> H+ + homovanillic_acid + S-adenosyl-L-homocysteine 2.1.1.6 catechol O-methyltransferase
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L-Dopa + O2 <=> dopaquinone + H2O 1.10.3
1.10.3.1 catechol oxidase
1.14.18.1 tyrosinase
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H2O + 4-Fumarylacetoacetate <=> H+ + fumarate + acetoacetate 3.7.1.2 fumarylacetoacetase
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normetanephrine + H2O + O2 <=> 4-hydroxyphenyl-3-methoxyglycolaldehyde + NH3 + H2O2 1.4.3.4 monoamine oxidase
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4-hydroxyphenylpyruvate + O2 <=> 4-hydroxyphenylacetate + CO2 1.2.3.13 4-hydroxyphenylpyruvate oxidase
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L-tyrosine + H2O + O2 <=> 4-hydroxyphenylpyruvate + NH3 + H2O2 1.4.3.11 L-glutamate oxidase
1.4.3.14 L-lysine oxidase
1.4.3.2 L-amino-acid oxidase
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5-oxopent-3-ene-1,2,5-tricarboxylate + H+ <=> 2-hydroxyhepta-2,4-dienedioate + CO2 4.1.1.68 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
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5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate_6-semialdehyde + NADP+ <=> stizolobinate + NADPH + H+ 1.13.11.30 stizolobinate synthase
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succinate_semialdehyde + NAD+ + H2O <=> NADH + succinate + H+ 1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.21 glycolaldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+)
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
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3,4-dihydroxyphenyllactic_acid + NAD+ <=> 3,4-Dihydroxyphenylpyruvate + NADH + H+ 1.1.1.237 hydroxyphenylpyruvate reductase
1.1.1.28 D-lactate dehydrogenase
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dopamine + O2 + ascorbate + H+ <=> norepinephrine + ascorbate + H2O 1.14.17.1 dopamine beta-monooxygenase
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L-tyrosine + O2 + H2O <=> 4-hydroxyphenylacetaldehyde + CO2 + NH3 + H2O2 4.1.1.108 4-hydroxyphenylacetaldehyde synthase
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4-Maleylacetoacetate <=> 4-Fumarylacetoacetate 5.2.1.2 maleylacetoacetate isomerase
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L-tyrosine <=> p-coumaric_acid + NH3 4.3.1.23 tyrosine ammonia-lyase
4.3.1.24 phenylalanine ammonia-lyase
4.3.1.25 phenylalanine/tyrosine ammonia-lyase
5.4.3.6 tyrosine 2,3-aminomutase
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(R)-3-(4-hydroxyphenyl)lactate + NAD+ <=> 4-hydroxyphenylpyruvate + NADH + H+ 1.1.1.110 aromatic 2-oxoacid reductase
1.1.1.222 (R)-4-hydroxyphenyllactate dehydrogenase
1.1.1.237 hydroxyphenylpyruvate reductase
1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.96 diiodophenylpyruvate reductase
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4-hydroxyphenylacetate + NADH + O2 <=> 3,4-Dihydroxyphenylacetate + NAD+ + H2O 1.14.12.9 4-chlorophenylacetate 3,4-dioxygenase
1.14.14.9 4-hydroxyphenylacetate 3-monooxygenase
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3-fumarylpyruvate + H2O <=> H+ + fumarate + pyruvate 3.7.1
3.7.1.20 3-fumarylpyruvate hydrolase
3.7.1.5 acylpyruvate hydrolase
4.1.1.112 oxaloacetate decarboxylase
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(4-hydroxyphenyl)enolpyruvate <=> 4-hydroxyphenylpyruvate 5.3.2.1 phenylpyruvate tautomerase
5.3.2.6 2-hydroxymuconate tautomerase
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tyramine + O2 + H2O <=> 4-hydroxyphenylacetaldehyde + NH3 + H2O2 1.4.3.10 putrescine oxidase
1.4.3.21 primary-amine oxidase
1.4.3.22 diamine oxidase
1.4.3.4 monoamine oxidase
1.4.9.2 aralkylamine dehydrogenase (azurin)
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O2 + 3,4-Dihydroxyphenylacetate <=> H+ + 5-carboxymethyl-2-hydroxymuconate_semialdehyde 1.13.11.15 3,4-dihydroxyphenylacetate 2,3-dioxygenase
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N-Methyltyramine + S-adenosyl-L-methionine <=> Hordenine + S-adenosyl-L-homocysteine 2.1.1
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S-adenosyl-L-methionine + 3,4-dihydroxyphenylglycol <=> S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxyphenylglycol 2.1.1.6 catechol O-methyltransferase
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L-tyrosine + O2 <=> L-Dopa 1.10.3.1 catechol oxidase
1.14.18.1 tyrosinase
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S-adenosyl-L-methionine + dopamine <=> H+ + S-adenosyl-L-homocysteine + 3-methoxytyramine 2.1.1.6 catechol O-methyltransferase
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4-hydroxyphenylpyruvate + H+ <=> 4-hydroxyphenylacetaldehyde + CO2 4.1.1.72 branched-chain-2-oxoacid decarboxylase
4.1.1.74 indolepyruvate decarboxylase
4.1.1.80 4-hydroxyphenylpyruvate decarboxylase
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2,5-Dihydroxybenzoate + H2O2 <=> 2,5-dihydroxybenzaldehyde + O2 + H2O 1.2.3.1 aldehyde oxidase
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3-hydroxyphenylacetate + O2 + NADH + H+ <=> 3,4-Dihydroxyphenylacetate + NAD+ + H2O 1.14.14.9 4-hydroxyphenylacetate 3-monooxygenase
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norepinephrine + H2O + O2 <=> 3,4-dihydroxyphenylglycolaldehyde + NH3 + H2O2 1.4.3.4 monoamine oxidase
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4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate_6-semialdehyde + NADP+ <=> stizolobate + NADPH + H+ 1.13.11.29 stizolobate synthase
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4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate_6-semialdehyde + NAD+ <=> stizolobate + NADH + H+ 1.13.11.29 stizolobate synthase
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3-methoxy-4-hydroxyphenylacetaldehyde + NAD+ + H2O <=> homovanillic_acid + NADH + H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
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4-hydroxyphenylacetate + O2 + NADH + H+ <=> homogentisate + H2O + NAD+ 1.14.13.18 4-hydroxyphenylacetate 1-monooxygenase
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maleylpyruvate + H2O <=> H+ + Maleate + pyruvate 3.7.1.23 maleylpyruvate hydrolase
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2-hydroxyhepta-2,4-dienedioate + H2O <=> 2,4-Dihydroxyhept-2-enedioate 4.2.1
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L-tyrosine + L-Dopa + O2 <=> L-Dopa + dopaquinone + H2O 1.10.3.1 catechol oxidase
1.14.18.1 tyrosinase
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3-methoxy-4-hydroxyphenylacetaldehyde + NADP+ + H2O <=> homovanillic_acid + NADPH + H+ 1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
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4-chlorophenylacetate + NADH + O2 <=> 3,4-Dihydroxyphenylacetate + Cl- + NAD+ 1.14.12.9 4-chlorophenylacetate 3,4-dioxygenase
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homogentisate + O2 + NADPH <=> 2,5-dihydroxybenzaldehyde + CO2 + NADP+ + H+ + H2O 4.1.1
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2-oxohept-3-enedioate <=> 2-hydroxyhepta-2,4-dienedioate 5.3.2.6 2-hydroxymuconate tautomerase
5.3.3
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2-oxohept-3-enedioate + H2O <=> 2,4-Dihydroxyhept-2-enedioate 4.2.1
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L-Dopa + O2 <=> 3,4-Dihydroxyphenylpyruvate + NH3 1.13.12.15 3,4-dihydroxyphenylalanine oxidative deaminase
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L-Dopachrome <=> 5,6-Dihydroxyindole-2-carboxylate 5.3.3.12 L-dopachrome isomerase
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3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O <=> 3,4-dihydroxymandelate + NADH + H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
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3-methoxytyramine + H2O + O2 <=> 3-methoxy-4-hydroxyphenylacetaldehyde + H2O2 + NH3 1.4.3.4 monoamine oxidase
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L-Dopa + O2 + H2O <=> 3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2 4.1.1.107 3,4-dihydroxyphenylacetaldehyde synthase
4.1.1.108 4-hydroxyphenylacetaldehyde synthase
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3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O <=> H+ + 3,4-Dihydroxyphenylacetate + NADH 1.2.1.29 aryl-aldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.39 phenylacetaldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
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2,5-dihydroxybenzaldehyde + NAD+ <=> 2,5-Dihydroxybenzoate + NADH 1.2.1.29 aryl-aldehyde dehydrogenase
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L-Dopa + O2 <=> H+ + 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate_6-semialdehyde 1.13.11.30 stizolobinate synthase
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4-hydroxyphenylacetate + O2 + NADPH + H+ <=> homogentisate + H2O + NADP+ 1.14.13.18 4-hydroxyphenylacetate 1-monooxygenase
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L-tyrosine + pyruvate <=> 4-hydroxyphenylpyruvate + L-alanine 2.6.1.12 alanine---oxo-acid transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.5 tyrosine transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.58 phenylalanine(histidine) transaminase
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S-adenosyl-L-methionine + L-adrenaline <=> metanephrine + S-adenosyl-L-homocysteine + H+ 2.1.1.6 catechol O-methyltransferase
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L-Dopa + 2-oxoglutarate <=> 3,4-Dihydroxyphenylpyruvate + L-glutamate 2.6.1.27 tryptophan transaminase
2.6.1.49 dihydroxyphenylalanine transaminase
2.6.1.5 tyrosine transaminase
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5-carboxymethyl-2-hydroxymuconate_semialdehyde + H2O + NADP+ <=> 5-Carboxymethyl-2-hydroxymuconate + NADPH 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
1.2.1.60 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
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dopamine + H2O + O2 <=> 3,4-dihydroxyphenylacetaldehyde + NH3 + H2O2 1.4.3.21 primary-amine oxidase
1.4.3.22 diamine oxidase
1.4.3.4 monoamine oxidase
1.4.9.2 aralkylamine dehydrogenase (azurin)
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H+ + L-tyrosine <=> CO2 + tyramine 4.1.1.25 tyrosine decarboxylase
4.1.1.28 aromatic-L-amino-acid decarboxylase
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dopaquinone + L-cysteine <=> Cysteinyldopa not assigned
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4-hydroxyphenylpyruvate + O2 <=> CO2 + homogentisate 1.13.11.27 4-hydroxyphenylpyruvate dioxygenase
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L-tyrosine + H2O + NAD+ <=> 4-hydroxyphenylpyruvate + NH3 + NADH 1.4.1.20 phenylalanine dehydrogenase
1.4.1.5 L-amino-acid dehydrogenase
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L-tyrosine + H2O <=> phenol + pyruvate + NH3 4.1.99.2 tyrosine phenol-lyase
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4-hydroxyphenylacetyl-CoA + glycine <=> p-Hydroxyphenylacetylglycine + CoA 2.3.1
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L-tyrosine + H2O2 <=> L-Dopa + H2O 1.11.2.6 L-tyrosine peroxygenase
1.14.18.1 tyrosinase
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1H-indole-5,6-dione + O2 <=> Eumelanin + H2O not assigned
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S-adenosyl-L-methionine + 3,4-dihydroxymandelate <=> vanillylmandelic_acid + S-adenosyl-L-homocysteine + H+ 2.1.1.6 catechol O-methyltransferase
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Hydroiodic_acid + 3,5-diiodo-L-tyrosine <=> 3-iodo-L-tyrosine + Iodine 1.11.1.8 iodide peroxidase
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3,4-dihydroxyphenylglycolaldehyde + NADP+ + H2O <=> 3,4-dihydroxymandelate + NADPH + H+ 1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
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stizolobinate + NADH + H+ <=> 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate_6-semialdehyde + NAD+ 1.13.11.30 stizolobinate synthase
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5-Carboxymethyl-2-hydroxymuconate <=> (3E,5R)-5-carboxy-2-oxohept-3-enedioate 5.3.3.10 5-carboxymethyl-2-hydroxymuconate Delta-isomerase
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3,4-dihydroxyphenyllactic_acid + NADP+ <=> 3,4-Dihydroxyphenylpyruvate + NADPH + H+ 1.1.1.237 hydroxyphenylpyruvate reductase
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3,4-dihydroxyphenylacetaldehyde + NADP+ + H2O <=> 3,4-Dihydroxyphenylacetate + NADPH + H+ 1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
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(R)-3-(4-hydroxyphenyl)lactate + NADP+ <=> 4-hydroxyphenylpyruvate + NADPH + H+ 1.1.1.110 aromatic 2-oxoacid reductase
1.1.1.237 hydroxyphenylpyruvate reductase
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L-Dopa + NADH + H+ <=> 3,4-Dihydroxyphenylpropionate + NAD+ + NH3 4.3.1.22 3,4-dihydroxyphenylalanine reductive deaminase
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4-hydroxyphenylacetaldehyde + NADP+ + H2O <=> 4-hydroxyphenylacetate + NADPH + H+ 1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
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3,4-Dihydroxyphenylpropionate <=> 3,4-dihydroxyphenyllactic_acid not assigned
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L-tyrosine + tetrahydrobiopterin + O2 <=> L-Dopa + dihydrobiopterin + H2O 1.14.16.2 tyrosine 3-monooxygenase
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S-adenosyl-L-methionine + norepinephrine <=> normetanephrine + S-adenosyl-L-homocysteine + H+ 2.1.1.6 catechol O-methyltransferase
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S-adenosyl-L-methionine + norepinephrine <=> H+ + S-adenosyl-L-homocysteine + L-adrenaline 2.1.1.28 phenylethanolamine N-methyltransferase
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4-hydroxyphenylacetaldehyde + NAD+ + H2O <=> H+ + NADH + 4-hydroxyphenylacetate 1.2.1.29 aryl-aldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.53 4-hydroxyphenylacetaldehyde dehydrogenase
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L-adrenaline + H2O + O2 <=> 3,4-dihydroxyphenylglycolaldehyde + methylamine + H2O2 1.4.3.4 monoamine oxidase
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maleylpyruvate <=> 3-fumarylpyruvate 5.2.1.2 maleylacetoacetate isomerase
5.2.1.4 maleylpyruvate isomerase
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Cysteinyldopa <=> Phaeomelanin not assigned
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homogentisate + O2 <=> 2,5-dihydroxybenzaldehyde + CO2 + H2O 1.13.12
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3,4-dihydroxyphenyllactic_acid + caffeoyl-CoA <=> rosmarinic_acid + CoA 2.3.1.140 rosmarinate synthase
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2,5-Dihydroxybenzoate + O2 <=> maleylpyruvate + H+ 1.13.11.4 gentisate 1,2-dioxygenase
1.13.11.86 5-aminosalicylate 1,2-dioxygenase
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L-tyrosine + O2 <=> L-Dopa 1.10.3.1 catechol oxidase
1.14.18.1 tyrosinase
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H+ + L-Dopa <=> dopamine + CO2 4.1.1.22 histidine decarboxylase
4.1.1.25 tyrosine decarboxylase
4.1.1.28 aromatic-L-amino-acid decarboxylase
4.1.1.53 phenylalanine decarboxylase
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2-Carboxy-2,3-dihydro-5,6-dihydroxyindole + dopaquinone <=> L-Dopachrome + L-Dopa not assigned
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O2 + homogentisate <=> H+ + 4-Maleylacetoacetate 1.13.11.5 homogentisate 1,2-dioxygenase
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5,6-Dihydroxyindole-2-carboxylate + O2 <=> indole-5,6-quinone-2-carboxylic_acid + H2O 1.14.18
1.14.18.B1
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L-Dopa + O2 <=> H+ + 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate_6-semialdehyde 1.13.11
1.13.11.29 stizolobate synthase
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dopaquinone <=> H+ + 2-Carboxy-2,3-dihydro-5,6-dihydroxyindole not assigned
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Hydroiodic_acid + 3-iodo-L-tyrosine <=> Iodine + L-tyrosine 1.11.1.8 iodide peroxidase
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L-tyrosine + 2-oxoglutarate <=> 4-hydroxyphenylpyruvate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.2 alanine transaminase
2.6.1.24 diiodotyrosine transaminase
2.6.1.27 tryptophan transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.49 dihydroxyphenylalanine transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
2.6.1.79 glutamate---prephenate aminotransferase
2.6.1.9 histidinol-phosphate transaminase
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S-adenosyl-L-methionine + tyramine <=> H+ + S-adenosyl-L-homocysteine + N-Methyltyramine 2.1.1.27 tyramine N-methyltransferase
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3,4-dihydroxyphenylglycol + NAD+ <=> 3,4-dihydroxyphenylglycolaldehyde + NADH + H+ 1.1.1.1 alcohol dehydrogenase
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2,4-Dihydroxyhept-2-enedioate <=> succinate_semialdehyde + pyruvate 4.1.2
4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
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L-glutamate + 4-hydroxyphenylacetyl-CoA <=> CoA + 4-Hydroxyphenylacetylglutamic_acid 2.3.1.14 glutamine N-phenylacetyltransferase
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5,6-dihydroxyindole + O2 <=> 1H-indole-5,6-dione + H2O 1.14.18.1 tyrosinase
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4-hydroxyphenyl-3-methoxyglycolaldehyde + NAD+ + H2O <=> vanillylmandelic_acid + NADH + H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
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5-carboxymethyl-2-hydroxymuconate_semialdehyde + NAD+ + H2O <=> H+ + 5-Carboxymethyl-2-hydroxymuconate + NADH 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
1.2.1.60 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
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metanephrine + H2O + O2 <=> 4-hydroxyphenyl-3-methoxyglycolaldehyde + methylamine + H2O2 1.4.3.4 monoamine oxidase
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5,6-Indolequinone-2-carboxylic_acid <=> Eumelanin not assigned
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H+ + L-Dopachrome <=> 5,6-dihydroxyindole + CO2 not assigned
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4-hydroxyphenyl-3-methoxyglycolaldehyde + NADP+ + H2O <=> vanillylmandelic_acid + NADPH + H+ 1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
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3-iodo-L-tyrosine + 3,5-diiodo-L-tyrosine + H2O2 <=> 3,3',5-triiodo-L-thyronine + 2-aminoacrylate + 2 H2O 1.11.1.8 iodide peroxidase
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Visualization of the pathway